Gentamicin and Gentamicin C1 in the Treatment of Complicated Urinary Tract Infections: Comparative Study of Efficacy, Tolerance, and Pharmacokinetics
AUTOR(ES)
Mosegaard, Aage
RESUMO
The clinical efficacy, patient tolerance, and pharmacokinetics of gentamicin and the single component gentamicin C1 were studied after single and multiple doses in elderly male patients. Patient tolerance was extremely good at the dose levels used. There was some evidence of renal function impairment due to repeated intramuscular doses of gentamicin, but not gentamicin C1. The antibiotics were equally effective against the organisms present in the urine of these patients. The pharmacokinetics of the two antibiotic forms were similar, although gentamicin C1 appeared to have a larger distribution space.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429134Documentos Relacionados
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