Glomerulosclerosis is transmitted by bone marrow–derived mesangial cell progenitors
AUTOR(ES)
Cornacchia, Flavia
FONTE
American Society for Clinical Investigation
RESUMO
We found that ROP Os/+ (Os/+) mice had diffuse glomerulosclerosis and glomerular hypertrophy and that their mesangial cells (the vascular smooth muscle cells of the glomerulus) displayed an apparent sclerosing phenotype. Since mesangial cells are the major source of scar tissue in glomerulosclerosis, we postulated that the sclerosis phenotype was carried by mesangial cell progenitors and that this phenotype could be derived from the bone marrow (BM). Therefore, we transplanted BM from Os/+ mice into congenic ROP +/+ mice (+/+ mice), which have normal glomeruli. We found that glomeruli of +/+ recipients of Os/+ marrow contained the Os/+ genotype, were hypertrophied, and contained increased extracellular matrix. Clones of recipient glomerular mesangial cells with the donor genotype were found in all +/+ recipients that developed mesangial sclerosis and glomerular hypertrophy, whereas +/+ recipients of +/+ BM had normal glomeruli. Thus, the sclerotic (Os/+) or normal (+/+) genotype and phenotype were present in, and transmitted by, BM-derived progenitors. These data show that glomerular mesangial cell progenitors are derived from the BM and can deliver a disease phenotype to normal glomeruli. Glomerular lesions may therefore be perpetuated or aggravated, rather than resolved, by newly arriving progenitor cells exhibiting a disease phenotype.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=200982Documentos Relacionados
- Bone marrow-derived lymphoid cell lines from patients with agammaglobulinemia.
- One-step Bone Marrow-derived Cell Transplantation in Talar Osteochondral Lesions
- Bone marrow–derived progenitor cells in pulmonary fibrosis
- Bone Marrow-Derived Cathepsin K Cleaves SPARC in Bone Metastasis
- Ratio of blood and marrow-derived cells in bone marrow transplantation.