Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion

AUTOR(ES)

Schmieg, John

FONTE

National Academy of Sciences

RESUMO

It has been shown that dendritic cells (DCs) are able to present glycolipids to natural killer (NK) T cells in vivo. However, the essential role of DCs, as well as the role of other cells in glycolipid presentation, is unknown. Here, we show that DCs are the crucial antigen-presenting cells (APCs) for splenic NK T cells, whereas Kupffer cells are the key APCs for hepatic NK T cells. Both cell types stimulate cytokine production by NK T cells within 2 h of glycolipid administration, but only DCs are involved in the systemic, downstream responses to glycolipid administration. More specifically, CD8α+ DCs produce IL-12 in response to glycolipid presentation, which stimulates secondary IFN-γ production by NK cells in different organs. Different APCs participate in glycolipid presentation to NK T cells in vivo but differ in their involvement in the overall glycolipid response.

Documentos Relacionados

• Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells.
• Organ-Dependent Variation of Capsule Thickness in Cryptococcus neoformans during Experimental Murine Infection
• Enteral Immunization with Attenuated Recombinant Listeria monocytogenes as a Live Vaccine Vector: Organ-Dependent Dynamics of CD4 T Lymphocytes Reactive to a Leishmania major Tracer Epitope
• The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion
• Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor β repertoire and small clone size