Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.

AUTOR(ES)

Barry, D I

RESUMO

Norepinephrine-rich cell suspensions, prepared from the locus coeruleus region of rat fetuses, were grafted bilaterally into the hippocampus of rats made hypersensitive to hippocampal kindling by a neurotoxic lesion of the central catecholamine system. The animals with grafts showed a marked suppression of the onset and progression of kindling-induced epilepsy, and this effect was correlated with the degree of graft-derived noradrenergic innervation of the host hippocampal formation. We conclude that grafted neurons can modulate the excitability of epileptic brain regions.

Documentos Relacionados

• Kindling-induced changes in plasticity of the rat amygdala and hippocampus
• Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy
• A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.
• Gynaecomastia induced by phenytoin in men with epilepsy.
• A longitudinal assessment of seizure outcome and overall benefit from 100 cortectomies for epilepsy.