Granulocyte function and Pseudomonas burn wound infection.

AUTOR(ES)

McEuen, D D

RESUMO

Granulocyte function in burn injury has been evaluated with an in vitro animal assay. Bactericidal activity, using this technique, was markedly depressed only when granulocytes from scald burned rats were challenged with each of three strains of Pseudomonas aeruginosa in the presence of autologous postburn serum or heat-inactivated serum. Preincubation of postburn and normal serum at 37 degrees C for 1 h resulted in normal phagocytosis. These studies validate an investigation of plasma and/or granulocyte replacement therapy in the burned patient.

Documentos Relacionados

• Correlation between pseudomonas burn wound infection and granulocyte antibacterial activity.
• Efficacy of mupirocin in methicillin-resistant Staphylococcus aureus burn wound infection.
• Therapeutic Efficacy of “Nubiotics” against Burn Wound Infection by Pseudomonas aeruginosa
• Assessment of protease (elastase) as a Pseudomonas aeruginosa virulence factor in experimental mouse burn infection.
• Relation between surgical volume and postoperative wound infection.