Growth of Mycobacterium lepraemurinum in the mouse bone marrow: an ultrastructural study.
AUTOR(ES)
Brown, I N
RESUMO
The ultrastruct of the mouse bone marrow during the first 8 weeks after intravenous inoculation of animals with 10(9) Mycobacterium lepraemurium is described. The bacteria were almost exclusively in macrophages, which became converted to epithelioid cells after 8 weeks, at which time they were very heavily infected. The nature of the exceptionally rapid increase in numbers of bacteria in the bone marrow compared with other tissues early in the infection is discussed. It is concluded that a short doubling time of bacteria situated in the marrow is a more probable explanation than recruitment from elsewhere in the animal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=420738Documentos Relacionados
- Effects of gonadectomy and testosterone on lymphocytes in the bone marrow of the mouse: an electron microscopic study.
- Bone Marrow: Structure and Function
- Bone marrow: An extra-pancreatic hideout for the elusive pancreatic stem cell?
- Lymphoproliferations in the bone marrow: identification and evolution, classification and staging.
- Beyond bone marrow: a new source of stem cells