H-NS and RpoS regulate emergence of Lac Ara+ mutants of Escherichia coli MCS2.

AUTOR(ES)

Gómez-Gómez, J M

RESUMO

Two master growth-phase regulatory proteins, H-NS and sigmaS, are involved in the formation of araB-lacZ fusion clones of Escherichia coli MCS2. The stationary-phase sigma factor RpoS is strictly required for the appearance of such mutants, whereas the histone-like protein H-NS represses their emergence. Our results support the idea that genetic changes leading to adaptive mutation in this model system are regulated by physiological signal transduction networks.

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