Hand-mixed and Premixed Antibiotic-loaded Bone Cement Have Similar Homogeneity
AUTOR(ES)
McLaren, Alex C.
FONTE
Springer-Verlag
RESUMO
Since low-dose antibiotic-loaded bone cement (ALBC) was approved by the FDA for second-stage reimplantation after infected arthroplasties in 2003, commercially premixed low-dose ALBC has become available in the United States. However, surgeons continue to mix ALBC by hand. We presumed hand-mixed ALBC was not as homogeneous as commercially premixed ALBC. We assessed homogeneity by determining the variation in antibiotic elution by location in a batch, from premixed and hand-mixed formulations of low-dose ALBC. Four hand-mixed methodologies were used: (1) suspension—antibiotic powder in the liquid monomer; (2) no-mix—antibiotic powder added but not mixed with the polymer powder before adding monomer; (3) hand-stirred—antibiotic powder stirred into the polymer powder before the monomer was added; and (4) bowl-mix—antibiotic powder mixed into polymer powder using a commercial mixing bowl before the monomer was added. Antibiotic elution was measured using the Kirby-Bauer bioassay. None of the mixing methods had consistently dissimilar homogeneity of antibiotic distribution from the others. Based upon our data we conclude hand-mixed low-dose ALBC is not less homogeneous than commercially premixed formulations.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2690765Documentos Relacionados
- Randomized clinical trial of encapsulated and hand-mixed glass-ionomer ART restorations: one-year follow-up
- Three-dimensional Quantitative Porosity Characterization of Syringe- versus Hand-mixed Set Epoxy Resin Root Canal Sealer
- "Estudo comparativo do tratamento das artroplastias infectadas do quadril sem e com o uso do espaçador de cimento com antibiótico"
- Toll-Like Receptor 4-Deficient Mice Have Reduced Bone Destruction following Mixed Anaerobic Infection
- Antibiotic-impregnated cement and beads for orthopedic infections.