Helix geometry of single stranded DNA 'A' and 'B' forms from minimum energy conformations of dimeric subunits.
AUTOR(ES)
Hingerty, B
RESUMO
Low energy conformations with dihedral angles similar to those occurring in fibers of the 'A' and 'B' forms of DNAs have been calculated for the deoxydinucleoside phosphates dApdA, dCpdC, dTpdT, dGpdG and dGpdC (1-3). These conformers have been used as building blocks for generating larger single stranded polymers, whose helical parameters we have calculated. We find that single stranded 'A' and 'B' form helices tend to be narrower and more tightly wound than the duplexes obtained in fibers (4,5). This is consistent with experimental observations on single stranded fibers of poly (rC) (6). We also find that the different sequences have different helix geometries. In addition, it is observed that large variations in helix geometry for a given sequence are achievable at little energetic cost.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=341966Documentos Relacionados
- A model for the single stranded random coil form of polydeoxyadenylic acid from minimum energy conformations of the dimeric subunit.
- 'A' forms of RNAs in single strands, duplexes and RNA-DNA hybrids.
- Interaction of dimeric intercalating dyes with single-stranded DNA.
- Conformations of the Single-Stranded DNA of Bacteriophage M13*
- Reconstitution of thermostable ATPase capable of energy coupling from its purified subunits.
