HEPATITIS AND AUSTRALIA ANTIGEN: AUTOSOMAL RECESSIVE INHERITANCE OF SUSCEPTIBILITY TO INFECTION IN HUMANS*

AUTOR(ES)

Blumberg, B. S.

RESUMO

Examples of inherited susceptibility to infection controlled by genes segregating at one or a small number of loci have been identified in lower animals. In this study we report data on what appears to be a similar situation in humans. “Australia antigen” is an antigen found in the sera of patients with acute and chronic hepatitis, and it may actually be a form of virus. It is very common in many tropical areas, and people in these areas having the antigen appear to be hepatitis carriers. The antigen is detected by immuno-diffusion in agar gel (Ouchterlony method). Individuals with the antigen are designated Au(1) and those without it Au(0). Family studies involving 1797 different individuals residing on the island of Bougainville are consistent with the hypothesis that susceptibility to chronic infection with the “antigen” is controlled by an autosomal recessive gene (Au1). This confirms the conclusions previously arrived at from similar (but less extensive) studies on the island of Cebu. Individuals with this inherited susceptibility do not ordinarily have overt manifestations of hepatitis.

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