Hepatitis B Virus-Mediated Changes of Apolipoprotein mRNA Abundance in Cultured Hepatoma Cells

AUTOR(ES)

Norton, Pamela A.

FONTE

American Society for Microbiology

RESUMO

An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.

Documentos Relacionados

• Virus-mediated mRNA decay by hyperadenylation
• Attenuation of dengue virus infection by adeno-associated virus-mediated siRNA delivery
• Sendai virus-mediated lysis of liposomes requires cholesterol.
• Early step in Sendai virus-mediated rescue of Rous sarcoma virus from virogenic mammalian cells.
• Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.