Hepatoprotection via the IL-6/Stat3 pathway

AUTOR(ES)

Taub, Rebecca

FONTE

American Society for Clinical Investigation

RESUMO

Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.

Documentos Relacionados

• IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
• Rac1 mediates STAT3 activation by autocrine IL-6
• Crosstalk between PKCζ and the IL4/Stat6 pathway during T-cell-mediated hepatitis
• Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis.
• Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling