Hereditary multi-infarct dementia unlinked to chromosome 19q12 in a large Scottish pedigree: evidence of probable locus heterogeneity.
AUTOR(ES)
St Clair, D
RESUMO
Hereditary multi-infarct dementia is a rare autosomal dominant disorder that predominantly affects the cerebral white matter. A locus was recently mapped in French pedigrees to chromosome 19q12. We have examined a large Scottish pedigree with neuropathologically confirmed hereditary multi-infarct dementia using polymorphic DNA markers spanning the 19q12 region and found no evidence of linkage. This suggests that, as in familial Alzheimer's disease, there is more than one locus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1050181Documentos Relacionados
- Vascular and Multi-infarct Dementia
- Aetiological considerations and risk factors for multi-infarct dementia.
- Auditory long latency event-related potentials in Alzheimer's disease and multi-infarct dementia.
- Linkage of hereditary haemorrhagic telangiectasia to chromosome 9q34 and evidence for locus heterogeneity.
- Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia.
