Herpesvirus mRNAs Are Sorted for Export via Crm1-Dependent and -Independent Pathways
AUTOR(ES)
Soliman, Tarik M.
FONTE
American Society for Microbiology
RESUMO
Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=111772Documentos Relacionados
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