Herpesvirus Saimiri-Transformed Human CD4+ T-Cell Lines: an Efficient Target Cell System for the Analysis of Human Immunodeficiency Virus-Specific Cytotoxic CD8+ T-Lymphocyte Activity

AUTOR(ES)

Bauer, Monika

FONTE

American Society for Microbiology

RESUMO

Herpesvirus saimiri growth-transformed human CD4+ T lymphocytes were examined for their suitability as a target cell system for investigating human immunodeficiency virus (HIV)-specific HLA class I-restricted cytotoxic T-cell activity. Besides CD4, they express the chemokine receptors CCR5 and CXCR4, the common coreceptors of HIV. They are infectible by a range of HIV strains, including primary isolates, becoming efficient targets for CD8-positive HIV-specific cytotoxic T lymphocytes.

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