Heterogeneity of clonal lymphocytes with regard to bcl-2 protein concentration and cell size.

AUTOR(ES)

Bromidge, T J

RESUMO

The existence of subpopulations of clonal lymphocytes in patients with low grade lymphoproliferative disorders, with regard to both cell size and bcl-2 protein concentration is reported. Flow cytometric analysis showed that the lymphocytes with higher levels of bcl-2 corresponded to a subset of larger lymphocytes. Statistical analysis suggested that the increased concentration of bcl-2 was not accounted for by the increase in cell size and it is possible that these cells form a functionally distinct component of the clonal proliferation. One patient, analysed in greater detail during treatment with a purine analogue, showed the subpopulations to exhibit a differential sensitivity to chemotherapy.

Documentos Relacionados

• Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.
• Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
• Bcl-2 antiapoptotic protein mediates verotoxin II–induced cell death: possible association between Bcl-2 and tissue failure by E. coli O157:H7
• Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum
• Solution structure of the antiapoptotic protein bcl-2