Heterogeneity of DNA deletion in gamma delta beta-thalassemia.
AUTOR(ES)
Orkin, S H
RESUMO
By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=370639Documentos Relacionados
- Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia.
- A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.
- Human globin gene analysis for a patient with beta-o/delta beta-thalassemia.
- Resistance to infection in murine beta-thalassemia.
- ATA box transcription mutation in beta-thalassemia.