Heterogeneous expression of glycopeptide resistance in enterococci associated with transfer of vanB.

AUTOR(ES)

Hayden, M K

RESUMO

In mating experiments using a clinical strain that constitutively expresses vanB-encoded glycopeptide resistance, resistance transfer was detectable at a frequency of <10(-7) transconjugants/donor. Vancomycin MICs for transconjugants were 2- to 10-fold lower than those for the donor; both inducibly and constitutively resistant transconjugants were obtained. These findings demonstrate that the transfer of vanB among enterococci can be associated with substantial alterations in the level and control of glycopeptide resistance expression.

Documentos Relacionados

• Moderate-Level Resistance to Glycopeptide LY333328 Mediated by Genes of the vanA and vanB Clusters in Enterococci
• Identification and Characterization of vanB2 Glycopeptide Resistance Elements in Enterococci Isolated in Scotland
• Regulation of VanA- and VanB-Type Glycopeptide Resistance in Enterococci
• Prevalence of the vanB2 Gene Cluster in VanB Glycopeptide-Resistant Enterococci in the United Kingdom and the Republic of Ireland and Its Association with a Tn5382-Like Element
• Members of the Genera Paenibacillus and Rhodococcus Harbor Genes Homologous to Enterococcal Glycopeptide Resistance Genes vanA and vanB