High-level expression of the FtsA protein inhibits cell septation in Escherichia coli K-12.

AUTOR(ES)
RESUMO

DNA fragments encoding the ftsA gene were subcloned into plasmids downstream of a lac promoter or a tac promoter. These plasmid constructs, when transformed into wild-type and mutant strains, inhibited normal cell septation, causing the formation of long nonseptate filaments. This phenotype is due to overproduction of the FtsA protein.

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