HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase

AUTOR(ES)

Dong, Yuzhi

FONTE

American Society for Microbiology

RESUMO

Major histocompatibility complex class I-restricted CD8+ cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), l-alanine dehydrogenase (AlaDH), and l-glutamine synthetase (GlnS) proteins.

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