Human African trypanosomiasis of the CNS: current issues and challenges
AUTOR(ES)
Kennedy, Peter G.E.
FONTE
American Society for Clinical Investigation
RESUMO
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=338269Documentos Relacionados
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