Human anti-DNA antibody: reference standards for diagnosis and management of systemic lupus erythematosus.
AUTOR(ES)
Holian, J
RESUMO
A technique for the measurement of DNA binding activity of sera is described which uses primary internal reference standards in a Farr assay. This allows the DNA binding activity of test sera to be measured in relation to the reference standards and the results are expressed as units/ml. The use of this standardized assay has led to diminished interassay variation and close interlaboratory correlation, and has provided a clinically useful test. In survey using the standardized assay, normal sera were found to have binding activity which did not exceed 15 units/ml; 71% of patients with systemic lupus erythematosus (SLE) had levels greater than 25 units/ml; while only 8% of patients with diseases other than SLE had levels above 25 units/ml. Values between 15 and 25 units/ml appeared to have little diagnostic significance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1006445Documentos Relacionados
- Anti-DNA activity in systemic lupus erythematosus. A diagnostic and therapeutic guide.
- Proceedings: Anti-DNA antibodies in discoid lupus erythematosus.
- Anti-DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus.
- Anti-DNA antibodies in discoid lupus erythematosus. Follow-up study.
- Relation of titred peripheral pattern ANA to anti-DNA and disease activity in systemic lupus erythematosus.
