Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication
AUTOR(ES)
Zheng, Yong-Hui
FONTE
American Society for Microbiology
RESUMO
Recently, APOBEC3G has been identified as a host factor that blocks retroviral replication. It introduces G to A hypermutations in newly synthesized minus strand viral cDNA at the step of reverse transcription in target cells. Here, we identified the human APOBEC3F protein as another host factor that blocks human immunodeficiency virus type 1 (HIV-1) replication. Similar to APOBEC3G, APOBEC3F also induced G to A hypermutations in HIV genomic DNA, and the viral Vif protein counteracted its activity. Thus, APOBEC family members might have evolved as a general defense mechanism of the body against retroviruses, retrotransposons, and other mobile genetic elements.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=415831Documentos Relacionados
- Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction Factors
- APOBEC3G Incorporation into Human Immunodeficiency Virus Type 1 Particles
- Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G Packaging
- Human Immunodeficiency Virus Type 1 Replication Is Modulated by Host Cyclophilin A Expression Levels
- Multiple Blocks to Human Immunodeficiency Virus Type 1 Replication in Rodent Cells