Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.
AUTOR(ES)
Lu, M
RESUMO
Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=190981Documentos Relacionados
- Human cytomegalovirus infection inhibits G1/S transition.
- Human Cytomegalovirus 86-Kilodalton IE2 Protein Blocks Cell Cycle Progression in G1
- G1 to S phase cell cycle transition in somatic and embryonic stem cells
- The Small Subunit Processome Is Required for Cell Cycle Progression at G1
- Cellulose Synthesis Is Coupled to Cell Cycle Progression at G1 in the Dinoflagellate Crypthecodinium cohnii