Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo

AUTOR(ES)
FONTE

American Society for Microbiology

RESUMO

We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.

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