Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro.
AUTOR(ES)
Etchison, D
RESUMO
One of the characteristics of picornavirus infection of cells in tissue culture is a specific inhibition of utilization of host cell mRNA for protein synthesis. In this study we show that human rhinovirus 14 is similar to poliovirus in that the inhibition of host cell translation that occurs during infection correlates with the proteolytic cleavage of an Mr 220,000 subunit of the cap-binding protein complex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254840Documentos Relacionados
- Cap-binding complex protein p220 is not cleaved during echovirus 22 replication in HeLa cells.
- Poliovirus protease 3C (P3-7c) does not cleave P220 of the eucaryotic mRNA cap-binding protein complex.
- Localization of Cap-Binding Protein in Subcellular Fractions of HeLa Cells
- Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex.
- Isolation and structural characterization of cap-binding proteins from poliovirus-infected HeLa cells.
