Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase.
AUTOR(ES)
Bacchetti, S
RESUMO
The herpes simplex virus ribonucleotide reductase is associated with two viral proteins which are both immunoprecipitated by monoclonal antibodies specific for the enzyme. We separated the two proteins and showed that individual antibodies react solely with one or the other. In addition, antibodies to either protein can neutralize enzymatic activity. Our data demonstrate that the proteins are associated in a complex and constitute the subunits of the enzyme.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=252856Documentos Relacionados
- Identification and Separation of the Two Subunits of the Herpes Simplex Virus Ribonucleotide Reductase
- Herpes simplex virus specifies two subunits of ribonucleotide reductase encoded by 3'-coterminal transcripts.
- Characterization of the novel protein kinase activity present in the R1 subunit of herpes simplex virus ribonucleotide reductase.
- Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1.
- Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.