Identification of a cis-regulatory element involved in accumulation of human T-cell leukemia virus type II genomic mRNA.
AUTOR(ES)
Ohta, M
RESUMO
The X gene products of the human T-cell leukemia viruses type I and II are thought to be involved not only in viral replication but also in mediating the expression of certain cellular genes. These X gene products are known to be translated from doubly spliced viral mRNA, while viral structural proteins, such as the gag, pol, and env gene products, are translated from unspliced or singly spliced viral mRNA. One of the X gene products of human T-cell leukemia virus type II, tax2 protein, has been shown to be responsible for transcriptional stimulation from the viral long terminal repeat. The other X gene product(s) of human T-cell leukemia virus type II, the rex2 protein(s), is located in the nuclear fraction of virus-infected cells, but its function is not known. This article reports evidence that rex2 protein(s) enhances the accumulation of unspliced viral RNA by interacting posttranscriptionally, either directly or indirectly, with a cis-regulatory element downstream from the first splice donor site in the long terminal repeat.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=253553Documentos Relacionados
- Rev of human immunodeficiency virus and Rex of the human T-cell leukemia virus type I can counteract an mRNA downregulatory element of the transferrin receptor mRNA.
- Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.
- Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
- Repetitive structure in the long-terminal-repeat element of a type II human T-cell leukemia virus.
- Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat.