Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1.
AUTOR(ES)
Lu, Y C
RESUMO
The negative regulatory element of human immunodeficiency virus type 1 is a 260-nucleotide-long sequence that decreases the rate of RNA transcription initiation specified by the long terminal repeat. This region has the potential to bind several cellular transcription factors. Here it is shown that sequences which recognize the NFAT-1 and USF cellular transcription factors contribute to this negative regulatory effect. The sequences within the negative regulatory element which resemble the AP-1 site and the URS do not negatively regulate human immunodeficiency virus long terminal repeat transcription initiation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=248024Documentos Relacionados
- cis-acting sequences involved in human immunodeficiency virus type 1 RNA packaging.
- Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1.
- cis-acting regulatory regions in the long terminal repeat of simian foamy virus type 1.
- Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region.
- Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.