Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization.

AUTOR(ES)

Cheng-Mayer, C

RESUMO

The human immunodeficiency virus (HIV) type 1 displays a high degree of genetic variation, especially in the glycoprotein (gp120) domain of the envelope gene. To determine whether this genomic heterogeneity leads to the expression of independent HIV subtypes, 12 sera from HIV type 1 antibody-positive individuals were tested for their ability to neutralize 20 HIV isolates of various origins. Four distinct HIV subtypes with different sensitivity to serum neutralization were identified. These results suggest that a finite number of HIV subtypes exist and that the combined use of selected HIV isolates representing several subtypes may be necessary for the development of an effective vaccine.

Documentos Relacionados

• Contribution of virion ICAM-1 to human immunodeficiency virus infectivity and sensitivity to neutralization.
• A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization.
• Identification with monoclonal antibodies of glycoproteins of Marek's disease virus and herpesvirus of turkeys related to virus neutralization.
• Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization.
• Alteration of V3 loop context within the envelope of human immunodeficiency virus type 1 enhances neutralization.