Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.
AUTOR(ES)
Szurek, P F
RESUMO
ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, induces hind-limb paralysis in mice. The DNA of both the ts1 and Moloney murine leukemia virus TB env genes has been sequenced, and the encoded amino acid sequences have been deduced from the DNA sequences. Four amino acids in the ts1 envelope protein have been identified which may be responsible for the ts1 phenotype, which includes temperature sensitivity, nonprocessing of Pr80env, and neurovirulence.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=250539Documentos Relacionados
- Molecular cloning of two paralytogenic, temperature-sensitive mutants, ts1 and ts7, and the parental wild-type Moloney murine leukemia virus.
- Temperature-sensitive splicing defect of ts110 Moloney murine sarcoma virus is virus encoded.
- Temperature-sensitive viral RNA expression in Moloney murine sarcoma virus ts110-infected cells.
- The neurovirulent determinants of ts1, a paralytogenic mutant of Moloney murine leukemia virus TB, are localized in at least two functionally distinct regions of the genome.
- Preliminary characterization of a temperature-sensitive mutant of Moloney murine leukemia virus that produces particles at the restrictive temperature.