Identification of two functional forms of immunoglobulin G3-binding protein expressed by group A streptococci.

AUTOR(ES)

Pack, T D

RESUMO

Analysis of group A streptococcal immunoglobulin G (IgG)-binding protein reactivity with different human IgG3-myeloma proteins provided evidence for at least two functional forms of these molecules. Representative IgG3-binding molecules were isolated, biotinylated, and used as tracers in competitive binding assays. Cross-inhibition studies demonstrated the existence of two distinct patterns of IgG3-binding activity. Proteins of one form could be inhibited from binding to an IgG3-myeloma protein by streptococcal protein G while binding of the second form was not inhibited. These studies further underscore the extent of heterogeneity among immunoglobulin-binding proteins expressed by group A streptococci.

Documentos Relacionados

• Functional and serological analysis of type II immunoglobulin G-binding proteins expressed by pathogenic group A streptococci.
• Identification of a fibronectin-binding protein (GfbA) in pathogenic group G streptococci.
• Role of immunoglobulin G in platelet aggregation by viridans group streptococci.
• Immunoglobulin-binding structure on bovine group G streptococci different from type III Fc receptors on human group G streptococci.
• Isolation and molecular characterization of a novel albumin-binding protein from group G streptococci.