IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: immunopathological implications?
AUTOR(ES)
Johnson, P M
RESUMO
The cross-reaction of IgM-rheumatoid factors (IgM-RF) with a cell nuclear antigen has been further investigated by immunofluorescence procedures. This reaction appears to be optimal at pH 8-9, and fails to occur at pH 6.5. No evidence was obtained by immunofluorescence that IgM-RF bound to the cell nuclear antigen fixes complement. It would appear that the nuclear reactivity of IgM-RF may be of limited immunopathological significance, though this reaction is of note in understanding the behavioural nature of rheumatoid factors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1000626Documentos Relacionados
- Determination of IgA- and IgM-rheumatoid factors in patients with rheumatoid arthritis with and without nephropathy.
- Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.
- Cross-reactive idiotypes and common antigen binding specificities expressed by a series of murine B-cell lymphomas: etiological implications.
- Normal immunoglobulin G (IgG) for therapeutic use (intravenous Ig) contain antiidiotypic specificities against an immunodominant, disease-associated, cross-reactive idiotype of human anti-thyroglobulin autoantibodies.
- Synthesis of IgM, IgG and IgA in rheumatoid arthritis.