Immediate-early protein of pseudorabies virus is not continuously required to reinitiate transcription of induced genes.
AUTOR(ES)
Ahlers, S E
RESUMO
We examined the role of herpesvirus immediate-early proteins in inducing and maintaining transcription by using tsG, a temperature-sensitive mutant in the immediate-early gene of pseudorabies virus. Cells infected at the permissive temperature were shifted to the nonpermissive temperature. Initially, early gene transcription rates were similar at both temperatures. Early gene transcription subsequently decreased slowly over several hours. Our results suggest that immediate-early protein function is required only for the initial activation of early gene transcription and is not required for multiple reinitiation events from activated early genes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254090Documentos Relacionados
- Isolation of interleukin 2-induced immediate-early genes.
- Echovirus 1 replication, not only virus binding to its receptor, VLA-2, is required for the induction of cellular immediate-early genes.
- Binding of the pseudorabies virus immediate-early protein to single-stranded DNA.
- Immediate-early transcription from the channel catfish virus genome: characterization of two immediate-early transcripts.
- Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters.