Immune complexes, rheumatoid factors, and cellular immunological parameters in patients with giant cell arteritis.
AUTOR(ES)
Malmvall, B E
RESUMO
Circulating immune complexes were found in 2 of 15 patients with giant cell arteritis (GCA) by using a solid phase Clq enzyme linked immunoabsorbent assay (ELISA). The prevalence in controls was 5%. Rheumatoid factor could be demonstrated in 2 out of 27 patients and in 11% of the controls by using a similar ELISA technique. The prevalence of T cells in blood was similar in 25 patients with GCA and in controls. The blood lymphocyte blastogenic response to the mitogens, phytohaemagglutinin, concanavalin-A, and pokeweed mitogen did not differ in 25 untreated patients compared with controls. Stimulation of lymphocytes by arterial homogenates was tested in 8 patients. In no case could a significant simulation by obtained. We conclude that immune complexes and rheumatoid factors are present in the same low frequency in GCA patients as in the normal population, and that the studied parameters of cellular immunity appear to be normal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1000762Documentos Relacionados
- Circulating immune complexes in polymyalgia rheumatica and giant cell arteritis.
- Isolation and analysis of immune complexes from sera of patients with polymyalgia rheumatica and giant cell arteritis.
- T cell subsets and expression of immunological activation markers in the arterial walls of patients with giant cell arteritis.
- Giant cell arteritis.
- Tonic pupil with giant cell arteritis.