Immune-specific production of gamma interferon in human lymphocyte cultures in response to mumps virus.
AUTOR(ES)
Nakayama, T
RESUMO
The production of interferon (IFN) was investigated in human peripheral lymphocyte cultures stimulated by mumps virus. IFN-alpha and IFN-gamma were produced in lymphocyte cultures from immune donors. However, no IFN-gamma was produced in lymphocyte cultures from nonimmune donors. IFN-alpha was produced by B lymphocytes, and IFN-gamma was produced by T lymphocytes. An increase in the production of IFN-gamma resulted from the mixture of autologous macrophages in T-lymphocyte cultures. The production of IFN-gamma by T lymphocytes was found to depend on prior, possibly cellular, immunity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264881Documentos Relacionados
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