Immunological cross-reactivity in the absence of DNA homology between Pseudomonas toxin A and diphtheria toxin.
AUTOR(ES)
Sadoff, J C
RESUMO
The immunodominant determinant of Pseudomonas toxin A was shown to cross-react with a normally inaccessible determinant in fragment A of diphtheria toxin. Trypsin-treated diphtheria toxin and fragment A of diphtheria toxin inhibited binding of toxin A antibody to whole toxin A, whereas whole diphtheria toxin did not inhibit this reaction. However, even at the lowest stringency no hybridization was detected between diphtheria tox probe and Pseudomonas aeruginosa DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347520Documentos Relacionados
- DNA homology and immunological cross-reactivity between Aeromonas hydrophila cytotonic toxin and cholera toxin.
- Molecular basis of immunological cross-reactivity between Treponema pallidum and Treponema pertenue.
- Immunological cross-reactivity between Streptococcus mutans and human heart tissue examined by cross-immunization experiments.
- Immunological cross-reactivity of oral non-streptococcal bacteria with mammalian tissue.
- Molecular basis for serological cross-reactivity between enteroviruses.
