Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants.
AUTOR(ES)
Barletta, R G
RESUMO
The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less alpha-galactosidase activity inducible by raffinose than wild-type strains. Melibiose (an inducer in wild-type strains) failed to induce significant levels of alpha-galactosidase in the mutant strains. We hypothesize that melibiose use by S. mutans requires the interaction of the GtfA enzyme, or another gene product under the control of the gtfA promoter, with other gene product(s) involved in melibiose transport or hydrolysis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=313211Documentos Relacionados
- Analysis of the virulence of Streptococcus mutans serotype c gtfA mutants in the rat model system.
- Streptococcus mutans gtfA gene specifies sucrose phosphorylase.
- Cloned gtfA gene of Streptococcus mutans LM7 alters glucan synthesis in Streptococcus sanguis.
- Molecular organization and expression of the gtfA gene of Streptococcus mutans LM7.
- Sequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.
