Implications of Heavy Chain Disease Protein Sequences for Multiple Gene Theories of Immunoglobulin Synthesis
AUTOR(ES)
Terry, William D.
RESUMO
The sequence of the amino-terminal 34 amino acids of γ-heavy chain disease (γ-HCD) protein Hi is homologous with the amino-terminal region of immunoglobulin heavy chains. γ-heavy chain disease is smaller than a normal γ-chain, but has the carboxy-terminal composition expected for γ-chains and must, therefore, contain an internal deletion. Comparison of the Hi sequence with that of γ-heavy chain disease Zu, which also has an internal deletion, indicates that the site of internal deletion is not a constant characteristic of γ-heavy chain disease proteins.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283081Documentos Relacionados
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