In Vitro Antibacterial Activities of Phloxine B and Other Halogenated Fluoresceins against Methicillin-Resistant Staphylococcus aureus
AUTOR(ES)
Rasooly, Avraham
FONTE
American Society for Microbiology
RESUMO
Fluorescein dyes in which the benzoic acid moiety has been tetrachlorinated (50 to 100 μg/ml) inhibit in vitro Staphylococcus aureus growth (MIC, 25 μg/ml). Specifically, under standard room illumination, phloxine B at a concentration of 100 μg/ml killed 99% of the cultures (mid-log phase). It also reduced S. aureus CFU by 104. Structure-activity analysis revealed that the activity against S. aureus increases with the increase in the number of the substituting halogens in the hydroxyxanthene moiety.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=128710Documentos Relacionados
- Comparative in vitro activity of coumermycin against methicillin-resistant Staphylococcus aureus.
- In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus.
- Differing activities of quinolones against ciprofloxacin-susceptible and ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus.
- Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus.
- In vitro activity of AT-4140 against quinolone- and methicillin-resistant Staphylococcus aureus.
