In Vitro Comparison of Kanamycin, Kanendomycin, Gentamicin, Amikacin, Sisomicin, and Dibekacin Against 200 Strains of Pseudomonas aeruginosa

AUTOR(ES)

Paradelis, A. G.

RESUMO

The antimicrobial activity of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa was compared. Dibekacin was found to be the most active against the tested organisms, whereas the other aminoglycoside antibiotics fell in the following order of diminishing antibacterial potency: amikacin, sisomicin, gentamicin, kanendomycin, and kanamycin. Seven strains showed high-level resistance to gentamicin (minimal inhibitory concentration, 400 μg/ml), and two of them were also resistant to amikacin and sisomicin (minimal inhibitory concentration, 75 μg/ml). The minimal inhibitory concentration of dibekacin for these seven strains was 0.625 μg/ml.

Documentos Relacionados

• Comparative Activity of Sisomicin, Gentamicin, Kanamycin, and Tobramycin
• Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.
• In Vitro Comparison of Gentamicin, Tobramycin, Sisomicin, and Netilmicin
• Interrelationships Between Disk and Tube Dilution Sensitivity Tests for the Aminoglycoside Antibiotics Gentamicin, Kanamycin, Sisomicin, and Tobramycin
• Comparative Activity of Netilmicin, Gentamicin, Amikacin, and Tobramycin Against Pseudomonas aeruginosa and Enterobacteriaceae