In vitro proteolytic cleavage of the Escherichia coli Ada protein by the ompT gene product.
AUTOR(ES)
Sedgwick, B
RESUMO
Down regulation of the adaptive response to alkylation damage in Escherichia coli has been proposed to occur by proteolytic cleavage of the regulatory Ada protein. In this paper, it is shown that proteolysis of the Ada protein as observed in cell extracts is caused by the ompT gene product. This protease, however, was not involved in switching off the adaptive response in vivo.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=209889Documentos Relacionados
- Colicin cleavage by OmpT protease during both entry into and release from Escherichia coli cells.
- Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpT
- ompT: Escherichia coli K-12 Structural Gene for Protein a (3b)
- Complete nucleotide sequence and deduced amino acid sequence of the ompT gene of Escherichia coli K-12.
- Comparison of Escherichia coli K-12 outer membrane protease OmpT and Salmonella typhimurium E protein.