In Vitro Susceptibility of El Tor and Classical Vibrio cholerae Strains to Trimethoprim and Sulfamethoxazole
AUTOR(ES)
Northrup, Robert S.
RESUMO
Trimethoprim and sulfamethoxazole were tested individually and in combination against El Tor and classical biotype strains of Vibrio cholerae. Determinations of the minimal inhibitory concentration in liquid media and by an agardilution method showed that classical strains were uniformly more resistant to sulfamethoxazole than were El Tor strains. In agar-dilution studies, trimethoprim was equally active against both biotypes. Combination of the agents produced a synergistic action against all strains tested. Testing for susceptibility to sulfonamide is suggested as a possible method for differentiating between El Tor and classical biotypes of V. cholerae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444213Documentos Relacionados
- In Vitro Susceptibility of Shigella Strains to Trimethoprim and Sulfamethoxazole
- In vitro and in vivo cholera toxin production by classical and El Tor isolates of Vibrio cholerae.
- Comparison of Vibrio cholerae O139 with V. cholerae O1 classical and El Tor biotypes.
- Analysis of expression of toxin-coregulated pili in classical and El Tor Vibrio cholerae O1 in vitro and in vivo.
- In Vitro Susceptibility of Haemophilus influenzae to Trimethoprim-Sulfamethoxazole