In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element.

AUTOR(ES)

Pine, R

RESUMO

Constitutive and interferon-inducible DNase hypersensitive sites in vivo are located in interferon-stimulated gene promoters near sequences that specifically bind constitutive or interferon-inducible proteins in vitro. Induced sites and proteins are transient or maintained, depending on cell type. Interferon-stimulated gene transcription is transient or maintained in parallel.

Documentos Relacionados

• Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element.
• Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element.
• Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.
• Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding Complex
• Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells