In Vivo Induction of Apoptosis Correlating with Reduced Infectivity during Baculovirus Infection†
AUTOR(ES)
Clarke, Thomas E.
FONTE
American Society for Microbiology
RESUMO
Spodoptera frugiperda caterpillars were infected with a mutant of Autographa californica M nucleopolyhedrovirus lacking the antiapoptotic p35 gene. Viral infectivity, replication, and spread were substantially reduced compared to that of a control revertant virus. Terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling confirmed that apoptosis occurred in mutant-infected caterpillars, thus directly correlating reduced infectivity and in vivo induction of apoptosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=140947Documentos Relacionados
- Apoptosis reduces both the in vitro replication and the in vivo infectivity of a baculovirus.
- Induction of apoptosis by baculovirus transactivator IE1.
- Using Recombinant Coxsackievirus B3 To Evaluate the Induction and Protective Efficacy of CD8+ T Cells during Picornavirus Infection†
- Baculovirus DNA Replication-Specific Expression Factors Trigger Apoptosis and Shutoff of Host Protein Synthesis during Infection▿
- An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo.
