Inactivation of Clostridium botulinum toxin by ruminal microbes from cattle and sheep.

AUTOR(ES)

Allison, M J

RESUMO

Toxin from Clostridium botulinum type C was rapidly inactivated during incubation in vitro with ruminal contents from either a cow or a sheep. Fractions of ruminal contents from which cells had been removed by high-speed centrifugation did not inactivate toxin. Inactivation was associated with fractions containing bacteria, whereas fractions containing protozoa and relatively few bacteria were much less active. This activity may help explain the relatively greater tolerance by ruminants to oral doses of botulinum toxin than to toxin administered by other routes. The results are also pertinent to assays for botulinum toxin from gastrointestinal samples obtained postmortem.

Documentos Relacionados

• Morphological diversity of ruminal bacteriophages from sheep and cattle.
• Stabilities of Clostridium botulinum type B and C toxins in ruminal contents of cattle.
• Differentiation of Clostridium difficile Toxin from Clostridium botulinum Toxin by the Mouse Lethality Test
• Evolutionary genetics of Pasteurella haemolytica isolates recovered from cattle and sheep.
• Kinetics of the Thermal Inactivation of Type E Clostridium botulinum Toxin1