Inactivation of the Anterior Cingulate Cortex Impairs Extinction of Rabbit Jaw Movement Conditioning and Prevents Extinction-Related Inhibition of Hippocampal Activity
AUTOR(ES)
Griffin, Amy L.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Although past research has highlighted the involvement of limbic structures such as the anterior cingulate cortex (ACC) and hippocampus in learning, few have addressed the nature of their interaction. The current study of rabbit jaw movement conditioning used a combination of reversible lesions and electrophysiology to examine the involvement of the hippocampus and the ACC during acquisition, performance, and extinction. We found that microinfusions of procaine into the ACC did not significantly alter the rate of behavioral learning or the amplitude of hippocampal conditioned unit responses, but that they disrupted the rhythmic periodicity of conditioned jaw movements. During extinction, whereas controls showed a rapid decline in behavioral CRs and active inhibition of hippocampal unit responses, ACC lesioned rabbits showed a persistence of conditioning-related hippocampal activity and behavioral responding. The results show that the ACC can be important for adaptive suppression of conditioned behavior and suggest a crucial physiological modulation of hippocampus by ACC during extinction.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=523079Documentos Relacionados
- Trace but not delay fear conditioning requires attention and the anterior cingulate cortex
- Post-learning infusion of anisomycin into the anterior cingulate cortex impairs instrumental acquisition through an effect on reinforcer valuation
- Purkinje cell activity in the cerebellar anterior lobe after rabbit eyeblink conditioning
- Parsing executive processes: Strategic vs. evaluative functions of the anterior cingulate cortex
- Dissociation between conflict detection and error monitoring in the human anterior cingulate cortex