Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus

AUTOR(ES)

Vieira, Michele Juliane, Perosa, Sandra Regina, Argaãaraz, Gustavo Adolfo, Silva Jr, José Antônio, Cavalheiro, Esper Abrão, da Graça Naffah-Mazzacoratti, Maria

FONTE

Clinics

DATA DE PUBLICAÇÃO

2014-09

RESUMO

OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.

Documentos Relacionados

• Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life
• Enhanced Tonic GABA Current in Normotopic and Hilar Ectopic Dentate Granule Cells After Pilocarpine-Induced Status Epilepticus
• Evaluation of effects of dichloromethane fraction from Platonia insignis on pilocarpine-induced seizures
• Methyl ethyl ketone blocks status epilepticus induced by lithium-pilocarpine in rats
• Estudo das alterações do estado de mal epiléptico induzido por pilocarpina no cérebro de camundongos imunodeficientes BALB/c nude