Induction of interleukin (IL)-1beta and IL-8 mRNA expression in porcine macrophages by lipopolysaccharide from Serpulina hyodysenteriae.
AUTOR(ES)
Sacco, R E
RESUMO
Lipopolysaccharide (LPS) is a classic inducer of inflammatory cytokines and is a key virulence factor for most gram-negative pathogens. The effect of phenol-water (LPS) and butanol-water (endotoxin) extracts from Serpulina hyodysenteriae on inflammatory cytokine mRNA expression from porcine alveolar macrophages was investigated. The LPS and endotoxin extracts from S. hyodysenteriae induced a dose-dependent expression of interleukin 1beta (IL-1beta) and IL-8 which was weak compared with the responses induced by Escherichia coli LPS. In addition, the spirochetal extracts induced no detectable upregulation of mRNA expression for either IL-6 or tumor necrosis factor alpha.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=174382Documentos Relacionados
- Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta.
- Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells
- Induction of Adrenomedullin mRNA and Protein by Lipopolysaccharide and Paclitaxel (Taxol) in Murine Macrophages
- In vitro expression of tumor necrosis factor-α, interleukin 1β, and interleukin 8 mRNA by bovine macrophages following exposure to Porphyromonas levii
- Purification and characterization of NADH oxidase from Serpulina (Treponema) hyodysenteriae.