Induction of Protective Immunity to Listeria monocytogenes by Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain

AUTOR(ES)

Nagata, Toshi

FONTE

American Society for Microbiology

RESUMO

Listeria epitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated invariant chain peptide (CLIP) region was replaced by a Listeria Th epitope. Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-γ- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection.

Documentos Relacionados

• Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.
• Direct observation of disordered regions in the major histocompatibility complex class II-associated invariant chain.
• Regulation of the class II-associated invariant chain gene in normal and mutant B lymphocytes.
• Shared promoter elements between a viral superantigen and the major histocompatibility complex class II-associated invariant chain.
• Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs